Pianist Frank Melrose was the younger brother of music publishers and agents Walter and Lester Melrose, who ran Melrose Brothers Music store in Chicago and were very involved in the business end of the Chicago Jazz and Blues scene in the 1920s and 1930s. Frank left home at age sixteen and drifted around, settling in St. Louis and then Kansas City, where he played occasionally. Melrose was a big fan of Jelly Roll Morton who did business with his brothers. Morton and Frank were reputably friends and jammed together occasionally in clubs on the South Side of Chicago.

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