Nels Cline (born in Los Angeles in 1956) is an American guitarist and composer. Currently he is the lead guitarist of the rock band Wilco. Nels began to play guitar at age 12 when his twin brother, Alex Cline took up the drums. Cline is not classically trained. This gives him a unique avant-garde style that many other jazz guitarists fail to match, due to their probable conventional training. He is noted for his apt use of effects pedals and looping devices, which enhances his style and gives his approach to guitar and music a distinct sound.

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