Born in Omaha, Nebraska in 1943, Calvin Keys' musical legacy began early with his father Otis Keys, a man who is still described as Omaha's greatest natural drummer. Early on in his own musical career Calvin auditioned and played guitar with such greats as Eddie Cleanhead Vinson and bassist Gerald Holts. At age 17, he first hit the road with sax player Little Walkin' Willie and then followed in his father's footsteps to Kansas City, where his first gigs were with Preston Love of the Count Basie Orchestra and The Frank Edwards Organ Trio.

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